LVEDP: A Suggestive Predictor Of Mortality In Stemi Patients Undergoing Primary PCI
DOI:
https://doi.org/10.69980/ajpr.v28i1.153Abstract
Left ventricular end-diastolic pressure (LVEDP) is directly related to left ventricular (LV) compliance and intravascular volume and pressure, and one of the main consequences of LV diastolic dysfunction is increased LV Filling pressures.
In the context of coronary artery disease, elevated filling pressures can be caused by acute ischemia, an infarction scar, or myocardial hibernation. 1,2,3,4,5
Acute ischemia results in an upward and rightward shift of the diastolic pressure-volume curve, which may be due to various factors: calcium overload in cardiomyocytes resulting in late activation and incomplete relaxation, pericardial constriction due to increased atrial and ventricular volume, intra and interventricular asynchrony and papillary muscle dysfunction.6,7,8
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