Prevalence and pattern of psychiatric disorders in ulcerative colitis: A study of 200 patients in North India

Authors

  • Waseem Javid
  • Muneer Ahmad Baba
  • Showkat Ahmad Kadla
  • Nisar Ahmad Shah

DOI:

https://doi.org/10.69980/ajpr.v28i4.228

Keywords:

Ulcerative Colitis, Psychiatric disorders, Adjustment disorder, Depression

Abstract

Background: Ulcerative colitis (UC), a chronic inflammatory bowel disease, is frequently associated with psychiatric comorbidities, which can significantly impact disease course and quality of life. This study aimed to assess the prevalence and pattern of psychiatric disorders in UC patients in the Kashmir region.

Methods: A cross-sectional study was conducted at a tertiary care centre in Kashmir involving 200 diagnosed UC patients. Psychiatric evaluation was performed using the Hospital Anxiety and Depression Scale (HADS) and DSM-5 criteria. Clinical and demographic data were collected and analysed.

Results: Out of the 200 UC patients (mean age 37.2 ± 12.6 years; 54% male), 118 (59%) had at least one psychiatric disorder. The most prevalent conditions were: Depression – 46% (n=92), anxiety disorders – 38% (n=76), somatoform disorders – 11% (n=22), adjustment disorders – 8% (n=16). Psychiatric morbidity was significantly higher in patients with moderate to severe disease activity (p < 0.01), longer disease duration (>5 years), and those with a history of steroid use. Female patients showed a higher prevalence of anxiety and depression compared to males (p < 0.05).

Conclusion: Psychiatric disorders are highly prevalent among UC patients in Kashmir, with depression and anxiety being the most common. Routine psychiatric screening and integrated psychosocial support should be considered essential components of UC management.

Author Biographies

Waseem Javid

Senior Residents, Department of Gastroenterology, GMC Srinagar, 190010

Muneer Ahmad Baba

Senior Residents, Department of Gastroenterology, GMC Srinagar, 190010

Showkat Ahmad Kadla

Professors department of Gastroenterology, GMC Srinagar, 190010

Nisar Ahmad Shah

Professors department of Gastroenterology, GMC Srinagar, 190010

References

1. Marrie RA, et al. Nat Rev Gastroenterol Hepatol. 2015;12(3):173–86.

2. Graff LA, et al. Inflamm Bowel Dis. 2009;15(7):1105–15.

3. Walker JR, et al. Can J Gastroenterol. 2008;22(5):475–82.

4. Mikocka-Walus A, et al. J Psychosom Res. 2016;87:70–8.

5. Dutta U, et al. Indian J Gastroenterol. 2015;34(3):225–9.

6. Baxter AJ, et al. Psychol Med. 2014;44(3):603–16.

7. Salk RH, et al. Clin Psychol Rev. 2017;52:15–29.

8. Zhang CK, et al. Inflamm Bowel Dis. 2013;19(9):1904–11.

9. Fardet L, et al. Am J Psychiatry. 2012;169(4):351–7.

10. Stasi C, et al. World J Gastroenterol. 2014;20(22):7604–22.

11. Creed F. Gastroenterology. 2006;130(5):1342–56.

12. Drossman DA, et al. Gastroenterology. 1997;112(6):2120–36.

13. Foster JA, et al. Trends Neurosci. 2013;36(5):305–12.

14. Cryan JF, et al. Nat Rev Neurosci. 2019;20(1):35–46.

15. Mayer EA, et al. Nat Rev Gastroenterol Hepatol. 2015;12(8):453–66.

16. Dinan TG, et al. Nat Rev Gastroenterol Hepatol. 2017;14(2):69–70.

17. Clarke G, et al. Nat Rev Gastroenterol Hepatol. 2020;17(6):336–44.

18. Carabotti M, et al. Ann Gastroenterol. 2015;28(2):203–9.

19. Housen T, et al. Confl Health. 2019;13:58.

20. Sheikh TA, et al. J Med Sci. 2020;23(2):67–72.

21. Addolorato G, et al. J Clin Gastroenterol. 2008;42(3):296–301.

22. Mikocka-Walus A, et al. Inflamm Bowel Dis. 2015;21(6):1329–36.

23. Fuller-Thomson E, et al. Inflamm Bowel Dis. 2006;12(8):697–707.

24. Knowles SR, et al. Inflamm Bowel Dis. 2013;19(10):2234–44.

25. Szigethy E, et al. Am J Gastroenterol. 2007;102(7):1456–63.

26. Gracie DJ, et al. Aliment Pharmacol Ther. 2017;45(8):1030–40.

27. Maunder R, et al. J Psychosom Res. 2013;75(2):136–41.

28. Bernstein CN, et al. Am J Gastroenterol. 2010;105(1):233–9.

29. Goodhand JR, et al. Inflamm Bowel Dis. 2012;18(5):1042–51.

30. Nahon S, et al. Clin Res Hepatol Gastroenterol. 2012;36(6):407–12.

Downloads

Published

2025-04-26