The Impact of Long-Term Use of Proton Pump Inhibitors (PPIs) on Drug and Vitamin Absorption in Patients
DOI:
https://doi.org/10.69980/ajpr.v28i5.585Abstract
Proton Pump Inhibitors (PPIs) are among the most commonly prescribed medications worldwide for conditions related to excessive gastric acid production, such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. Their efficacy in suppressing gastric acid secretion has made them the drug of choice in both short-term and long-term management of acid-related disorders (Maideen, 2023).
References
References
1. Maideen N. M. P. (2023). Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors. Chonnam medical journal, 59(2), 115–127. https://doi.org/10.4068/cmj.2023.59.2.115
2. Losurdo, G., Caccavo, N. L. B., Indellicati, G., Celiberto, F., Ierardi, E., Barone, M., & Di Leo, A. (2023). Effect of Long-Term Proton Pump Inhibitor Use on Blood Vitamins and Minerals: A Primary Care Setting Study. Journal of clinical medicine, 12(8), 2910. https://doi.org/10.3390/jcm12082910
3. Lehault, W. B., & Hughes, D. M. (2017). Review of the Long-Term Effects of Proton Pump Inhibitors. Federal practitioner : for the health care professionals of the VA, DoD, and PHS, 34(2), 19–23.
4. Koyyada A. (2021). Long-term use of proton pump inhibitors as a risk factor for various adverse manifestations. Therapie, 76(1), 13–21. https://doi.org/10.1016/j.therap.2020.06.019
5. Jaynes, M., & Kumar, A. B. (2018). The risks of long-term use of proton pump inhibitors: a critical review. Therapeutic advances in drug safety, 10, 2042098618809927. https://doi.org/10.1177/2042098618809927
6. Wilhelm, S. M., Rjater, R. G., & Kale-Pradhan, P. B. (2013). Perils and pitfalls of long-term effects of proton pump inhibitors. Expert review of clinical pharmacology, 6(4), 443–451. https://doi.org/10.1586/17512433.2013.811206
7. Strand DS, Kim D, Peura DA. (2017). 25 Years of Proton Pump Inhibitors: A Comprehensive Review. Gut and Liver; 11: 27-37. https://doi.org/10.5009/gnl15502
8. Smaoui, H., Chtourou, L., Jallouli, D., Jemaa, S. B., Karaa, I., Boudabbous, M., Moalla, M., Gdoura, H., Mnif, L., Amouri, A., Akrout, R., Ayadi, F., Baklouti, S., & Tahri, N. (2024). Effect of long-term proton pump inhibitors on phosphocalcium metabolism and bone mineral density. Future science OA, 10(1), FSO977. https://doi.org/10.2144/fsoa-2023-0198
9. Freedberg, D. E., Kim, L. S., & Yang, Y. X. (2017). The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association. Gastroenterology, 152(4), 706–715. https://doi.org/10.1053/j.gastro.2017.01.031
10. Tan, C. M., & Juurlink, D. N. (2024). Navigating Drug Interactions with Proton Pump Inhibitors. JAMA network open, 7(7), e2419818. https://doi.org/10.1001/jamanetworkopen.2024.19818
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