Pharmacological Synergy: Systematic Review Of Glp-1 And Gip Receptor Co-Activation By Tirzepatide
DOI:
https://doi.org/10.69980/ajpr.v28i5.608Keywords:
Tirzepatide; GLP-1 receptor; GIP receptor; dual agonism; type 2 diabetes; obesity; incretin mimetics; metabolic syndrome; systematic reviewAbstract
Tirzepatide represents a breakthrough in metabolic therapeutics as a dual agonist of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors1. This systematic review synthesizes evidence on its pharmacological mechanisms, clinical efficacy, safety profile, and broader implications for type 2 diabetes and obesity management. Drawing from major clinical trials and mechanistic studies, Tirzepatide demonstrates superior glycemic control (mean HbA1c reduction of 1.8-2.6%) and weight loss (up to 25% body weight reduction) compared to single GLP-1 agonists2,3, attributed to synergistic receptor co-activation. Safety data indicate transient gastrointestinal effects as primary concerns, with low hypoglycemia risk4. Future research should explore long-term outcomes and pharmacogenomic influences to optimize personalized therapy.
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