Effect Of Continuous Positive Airway Pressure Therapy On Glycemic Control And Blood Pressure In Patients Having Obstructive Sleep Apnea
DOI:
https://doi.org/10.69980/ajpr.v28i5.612Keywords:
Obstructive sleep apnea, Continuous positive airway pressure, Fasting blood sugar level, HbA1c, Apnea-Hypopnea IndexAbstract
Introduction: OSA is a sleep disorder which causes repetitive episodes of complete or partial obstruction of upper airway during sleep which lead to Sleep fragmentation. Alterations in human body caused by untreated OSA likely contribute to development of insulin resistance and type 2 diabetes. Common treatment for obstructive sleep apnea is CPAP. CPAP eliminate OSA that help to breathe during sleep and prevent sleep fragmentation, and activation of the sympathetic nervous system. So, this study was conducted to find whether CPAP therapy in patients having OSA really improve glucose metabolism or not.
Materials and Method: First of all, written consent was taken then Polysomnography for all these subjects were done from 10 pm to 6 am at Sleep Research Centre, MGM Hospital, Kamothe Navi Mumbai. Apnea hypopnea index was obtained from polysomnogram. Subjects having AHI ≥ 5 were included in the study. After polysomnography recording is over, at around 6:30 am, fasting blood sample was collected for fasting blood glucose level and HbA1c investigation of these subjects. Then, for 2 months, subjects were made to use CPAP for 6 hours every night while sleeping. After Two months of CPAP use polysomnography recording and blood investigation of these subjects were done again. Then comparison between all parameters of subjects before CPAP use and after CPAP use were done.
Results: CPAP use increases sleep efficiency%, mean TBI SPo2%, SBP, DBP significantly. It decreases Apnea-Hypopnea Index (AHI) significantly. It also insignificantly decreases FBS, HbA1c%.
Conclusions: CPAP treatment reduces obstructive sleep apnea (OSA), increases oxygen saturation and sleep efficiency and improve glycemic control.
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