Compare the safety and efficacy of Propranolol versus Nortriptyline as Monotherapy for Migraine Prophylaxis.
DOI:
https://doi.org/10.69980/ajpr.v28i5.629Keywords:
.Abstract
Objective: To compare the safety and efficacy of Propranolol and Nortriptyline as monotherapy in the prophylactic treatment of migraine.
Methods: This study evaluated patients diagnosed with migraine who were treated with either Propranolol or Nortriptyline. The primary endpoints included reduction in frequency, severity, and duration of migraine attacks. Secondary outcomes assessed the tolerability and side effect profile of each medication.
Results: Nortriptyline demonstrated superior efficacy compared to Propranolol, significantly reducing the frequency, intensity, and duration of migraine episodes. However, Propranolol was better tolerated, with fewer and less severe side effects reported.
Conclusion: In This study indicates that Nortriptyline is more effective than Propranolol in migraine prevention, particularly in reducing the frequency, severity, and duration of attacks. However, Propranolol demonstrates better tolerability with fewer side effects. While Nortriptyline appears to be the more efficacious option for migraine prophylaxis, Propranolol may be preferred in patients who prioritize minimal adverse effects.
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