GC-MS Analysis, Antioxidant and Genotoxic Assessment of Medicinally Important Plant Paeonia emodi Wall Ex. Hook
DOI:
https://doi.org/10.69980/ajpr.v28i1.651Keywords:
GC-MS, antioxidant, genotoxic, Paeonia emodiAbstract
Paeonia emodi Wall Ex. Hook., a member of the Paeoniaceae family, is an herbaceous perennial plant. It survives in the winter through underground buds and is known for its large white flower and deeply divided leaves. Traditionally, it has been used to treat various ailments. The current study was carried out to find the bioactive compounds by GC-MS, antioxidant activity through DPPH, genotoxic activity through comet assay, GC-MS Chromatogram represents different compounds detected in the crude extract. Major pharmacological bioactive compounds are 4H-Pyran- 4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl- 4-Methyl, 10E,12Z-Octadecadienoic acid, 1,2-Cyclohexanedicarboxylic acid 1,4-Benzenedicarboxylic acid, bi..., 2-Pentanone, 4-hydroxy-4-methyl-, Eugenol; 9,12-Octadecadienoic acid (Z,Z); 1,4-Benzenedicarboxylic acid, bi...; 1-Piperidinecarboxaldehyde, 2- After 90 minutes at a concentration of 300 (g/ml), the methanolic extract showed the highest antioxidant activity (67.7±1.54), closely followed by the ethanolic extract (72.4±2.06). The methanolic and ethanolic extract show genotoxic activity (114.6±63.03), (169.7±71), and (173±87.38), (205.9±85.62) at 75, and 100 mg/100 ml, respectively at high dose. This study emphasizes that the plant is rich both micro and macro nutrients, has significant nutritional value, and shows notable pharmacological effects. These characteristics make it a promising candidate for developing treatments for various health conditions.
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