Effectiveness Of Lifestyle Interventions In Preventing Metabolic Syndrome In Primary Care: A Systematic Review
DOI:
https://doi.org/10.69980/ajpr.v28i5.662Keywords:
Metabolic syndrome; lifestyle intervention; primary care; prevention; diet; physical activity; behavior change; systematic reviewAbstract
Background:
Metabolic syndrome (MetS) is a growing global health challenge strongly associated with increased risks of type 2 diabetes and cardiovascular diseases. Primary care plays a pivotal role in delivering preventive lifestyle interventions targeting modifiable risk factors.
Objective:
This systematic review aimed to synthesize contemporary evidence on the effectiveness of lifestyle interventions—focusing on diet, physical activity, and behavior change—delivered within primary care settings to prevent or reverse MetS in at-risk adults.
Methods:
A systematic review was conducted according to PRISMA 2020 guidelines. Databases searched included PubMed, Scopus, Web of Science, Embase, and Google Scholar. Eligible studies were randomized controlled trials, cluster-RCTs, community trials, or systematic reviews/meta-analyses published in English from 2000 to 2025. Data extraction and risk-of-bias assessment were performed by independent reviewers.
Results:
Fifteen studies met inclusion criteria, comprising diverse populations and intervention formats. Findings consistently showed that structured lifestyle interventions reduced MetS incidence by 20–69% compared to usual care. Significant improvements were observed in weight, waist circumference, blood pressure, glucose, and dietary quality. Successful programs often used multi-component strategies, cultural tailoring, and group support.
Conclusion:
Lifestyle interventions delivered in primary care are effective, feasible, and cost-effective for preventing MetS. Embedding structured behavioral support and culturally adapted approaches can enhance implementation and sustainability.
References
• Ard, J. D., et al. (2007). Effects of PREMIER lifestyle modifications on participants with and without the metabolic syndrome. Hypertension, 50(4), 609–616.
• Assadi, F., Mazaheri, M., & Kelishadi, R. (2022). The role of healthy lifestyle in the primordial prevention of metabolic syndrome throughout lifetime: What we know and what we need to know. In Healthy Lifestyle: From Pediatrics to Geriatrics (pp. 17–26). Springer.
• Bihan, H., Takbou, K., Cohen, R., Michault, A., Boitou, F., & Pene, J. (2009). Impact of short-duration lifestyle intervention in collaboration with general practitioners in patients with the metabolic syndrome. Diabetes & Metabolism, 35(5), 381–386.
• Bo, S., et al. (2007). Effectiveness of a lifestyle intervention on metabolic syndrome. Journal of General Internal Medicine, 22(12), 1695–1703.
• Brauer, P., et al. (2019). Nutrient intake and dietary quality changes within a personalized lifestyle intervention program for metabolic syndrome in primary care. Applied Physiology, Nutrition, and Metabolism, 44(6), 581–590.
• Chan, B. S., et al. (2024). Comparative effectiveness of primary prevention interventions on metabolic syndrome: A systematic review. SSRN.
• Feldman, I., et al. (2013). Heterogeneity in cost-effectiveness of lifestyle counseling for metabolic syndrome. Cost Effectiveness and Resource Allocation, 11, 19.
• Gomez-Huelgas, R., et al. (2015). Effects of a long-term lifestyle intervention program with Mediterranean diet and exercise. European Journal of Internal Medicine, 26(7), 531–536.
• Guzmán, M., Zbella, E., Alvarez, S. S., & Fernández, F. (2020). Effect of an intensive lifestyle intervention on the prevalence of metabolic syndrome and its components among overweight and obese adults. Journal of Public Health, 42(4), 828–834.
• Iurciuc, M., et al. (2011). Dietary and physical activity counseling in high-risk asymptomatic patients with metabolic syndrome—a primary care intervention. Journal of Food, Agriculture & Environment.
• Khalili, D., et al. (2019). Long-term effectiveness of a lifestyle intervention: A pragmatic community trial to prevent metabolic syndrome. American Journal of Preventive Medicine, 56(2), 217–227.
• Kim, D., Yoon, S. J., Lim, D. S., Gong, Y. H., Ko, S., & Lee, Y. H. (2016). The preventive effects of lifestyle intervention on the occurrence of diabetes mellitus and acute myocardial infarction in metabolic syndrome. Public Health, 139, 52–58.
• Kuninkaanniemi, H., Villberg, J., & Kumpusalo, E. (2011). Behaviour‐change interventions in primary care: Influence on nutrition and on the metabolic syndrome definers. International Journal of Nursing Practice, 17(2), 127–134.
• Laaksonen, D. E., et al. (2008). Determinants for the effectiveness of lifestyle intervention in the Finnish Diabetes Prevention Study. Diabetes Care, 31(5), 857–862.
• Ma, J., et al. (2009). Evaluation of lifestyle interventions to treat elevated cardiometabolic risk in primary care (E-LITE): A randomized controlled trial. BMC Family Practice, 10, 71.
• Ma, J., et al. (2013). Translating the DPP lifestyle intervention for weight loss into primary care: A randomized trial. JAMA Internal Medicine, 173(2), 113–121.
• Nakao, Y. M., Miyamoto, Y., Ueshima, K., Nakao, K., Nakai, M., & Noda, M. (2018). Nationwide lifestyle intervention for abdominal obesity and cardiometabolic risks in Japan: The metabolic syndrome and comprehensive lifestyle intervention study. PLoS One, 13(2), e0190862.
• Neeland, I. J., Lim, S., Tchernof, A., & Gastaldelli, A. (2024). Metabolic syndrome. Nature Reviews Disease Primers, 10, 2–19.
• Patterson, E., Munn, Z., & Jennings, C. (2020). Experiences of providers in delivering nutrition-focused lifestyle interventions for adults with obesity or metabolic syndrome in primary healthcare settings: A qualitative systematic review. JBI Evidence Synthesis, 18(7), 1398–1443.
• Peltonen, M., et al. (2021). Long-term outcomes of lifestyle intervention to prevent T2DM in people at high risk in primary health care. Primary Care Diabetes, 15(2), 241–248.
• Prendergast, L., & Peiris, C. (2019). A systematic review of multifaceted lifestyle interventions for people with metabolic syndrome. Metabolism, 95, 36–47.
• Scott, C. L. (2003). Diagnosis, prevention, and intervention for the metabolic syndrome. The American Journal of Cardiology, 92(1), 35i–42i.
• Watanabe, M., et al. (2017). Effects of a lifestyle modification programme for metabolic syndrome: A RCT. Public Health Nutrition, 20(10), 1788–1795.
• Whitlock, E. P., et al. (2011). Effectiveness of primary care–relevant treatments for obesity in adults. Annals of Internal Medicine, 155(7), 434–447.
• Yamaoka, K., & Tango, T. (2012). Effects of lifestyle modification on metabolic syndrome: A systematic review and meta-analysis. BMC Medicine, 10(1), 138.
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