The Code Of Righteous Living (Sadvritta): An Ayurvedic Framework For Immunomodulation Via Psychoneuroimmunology And Chronobiological Alignment

Abstract

The contemporary global disease burden is increasingly dominated by non-communicable and lifestyle-related disorders characterized by chronic inflammation, circadian disruption, psychosocial stress, and impaired host defense. This shift necessitates preventative, non-pharmacological frameworks that integrate biological, psychological, and social determinants of health. Ayurveda conceptualizes immunity and disease resistance through Vyadhikshamatva, a dynamic expression of metabolic integrity (Agni), tissue vitality (Dhatu Bala), and the preservation of Ojas, the vital essence sustaining life and resilience. Central to this preventative paradigm is Sadvritta—the Code of Righteous Living—described in classical Ayurvedic texts as disciplined conduct encompassing physical, mental, ethical, social, and spiritual domains. Sadvritta as an Achara Rasayana (behavioral rejuvenative therapy) and elucidates its immunomodulatory role through contemporary scientific frameworks, including psychoneuroimmunology, chronobiology, and the gut–immune axis. By regulating daily routines (Dinacharya), emotional discipline (Manasika Sadvritta), ethical and prosocial behavior (Samajika Sadvritta), and mindful dietary practices (Ahara Vidhi Vidhana), Sadvritta mitigates allostatic load, stabilizes the hypothalamic–pituitary–adrenal axis, preserves circadian rhythmicity, and supports microbiome integrity. These mechanisms collectively enhance innate and adaptive immune functions, reduce systemic inflammation, and promote immunological memory.