Association of ABO Blood Groups with Peptic Ulcer Disease and Gastric Carcinoma
DOI:
https://doi.org/10.69980/ajpr.v28i1.853Abstract
Abstract
Background: The ABO blood group system has been consistently associated with susceptibility to various gastrointestinal diseases, notably peptic ulcer disease and gastric carcinoma, as evidenced by epidemiological studies. However, data from Indian populations, particularly in hospital-based observational contexts, remain sparse. Methods: This prospective observational study involved 40 patients diagnosed with either peptic ulcer disease or gastric carcinoma, all of whom underwent upper gastrointestinal endoscopy at a tertiary care teaching hospital. The cohort comprised 20 patients with peptic ulcer disease and 20 with gastric carcinoma. ABO blood grouping was conducted using the rapid-slide agglutination method. The frequency distribution of ABO blood groups was analyzed separately for peptic ulcer disease and gastric carcinoma. Results: Among the patients with peptic ulcer disease, blood group O was the most prevalent, identified in 11 patients (55%), followed by blood groups A, B, and AB. In contrast, blood group A was predominant among patients with gastric carcinoma, observed in 14 patients (70%). Individuals with blood group O exhibited a higher relative risk for peptic ulcer disease, whereas those with blood group A demonstrated a higher relative risk for gastric carcinoma compared to other blood groups. Conclusion: This study corroborates the association between blood group O and peptic ulcer disease, as well as between blood group A and gastric carcinoma. These findings underscore the potential influence of genetic and biological factors linked to ABO blood groups in the pathogenesis of gastrointestinal diseases. Further extensive studies incorporating additional risk factors are necessary to elucidate these associations.
References
1. Chen Z, Yang SH, Xu H, Li JJ. ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis. Sci Rep. 2016 Mar 18;6(1).
2. Mannucci PM, Franchini M. ABO blood group and thrombotic vascular disease. Thromb Haemost. 2014 Jan 1;112(6):1103–1109.
Doll R, Newell AC, Drane H. Secretion of blood group substances in duodenal, gastric and stomal ulcer, gastric carcinoma, and diabetes mellitus. Gut. 1961 Dec 1;2(4):352–359.
3. Buckwalter JA. ABO blood groups and disease. JAMA. 1956 Nov 24;162(13):1210.
Edgren G, Melbye M, Rostgaard K, Wikman A, Norda R, Hjalgrim H, et al. Risk of Gastric Cancer and Peptic Ulcers in Relation to ABO Blood Type: A Cohort Study. American Journal of Epidemiology. 2010 Oct 11;172(11):1280–1285.
Priya S, Burns MB, Ward T, Mars RAT, Adamowicz B, Lock EF, et al. Identification of shared and disease-specific host gene–microbiome associations across human diseases using multi-omic integration. Nat Microbiol. 2022 May 16;7(6):780–795.
Cooling L. Blood Groups in Infection and Host Susceptibility. Clin Microbiol Rev. 2015 June 17;28(3):801–870.
Mccoll KEL, Gillen D, El-Omar E. Interactions between H. pylori infection, gastric acid secretion and anti-secretory therapy. British Medical Bulletin. 1998 Jan 1;54(1):121–138.
4. Wang Z, Yu Y, Ji J, Liu B, Zhang J, Zhang J, et al. ABO blood group system and gastric cancer: a case-control study and meta-analysis. IJMS. 2012 Oct 17;13(10):13308–13321.
5. Höök-Nikanne J, Kosunen TU, Sistonen P. Effect of ABO Blood Group and Secretor Status on the Frequency ofHelicobacter pyloriAntibodies. Scandinavian Journal of Gastroenterology. 1990 Jan 1;25(8):815–818.
Franchini M, Liumbruno GM, Lippi G. The prognostic value of ABO blood group in cancer patients. Blood transfusion = Trasfusione del sangue. 2015 Nov 6;14(5):434–40.
6. Lindén S, Mahdavi J, Semino-Mora C, Olsen C, Carlstedt I, Borén T, et al. Role of ABO Secretor Status in Mucosal Innate Immunity and H. pylori Infection. PLoS Pathog. 2008 Jan 1;4(1):e2.
7. Chakrani Z, Taye B, Robinson K. Association Between ABO Blood Groups and Helicobacter pylori Infection: A Meta-Analysis. Sci Rep. 2018 Dec 1;8(1).
8. Dickey W, Porter KG, Sloan JM, Watson RG, Collins JS. Secretor status and Helicobacter pylori infection are independent risk factors for gastroduodenal disease. Gut. 1993 Mar 1;34(3):351–353.
9. Robertson MS, Cade JF, Savoia HF, Clancy RL. Helicobacter pylori infection in the Australian community: current prevalence and lack of association with ABO blood groups. Internal Medicine Journal. 2003 Apr 1;33(4):163–167.
Risch HA, Kidd MS, Lu L, Yu H. ABO Blood Group, Helicobacter pylori Seropositivity, and Risk of Pancreatic Cancer: A Case-Control Study. JNCI Journal of the National Cancer Institute. 2010 Feb 24;102(7):502–505.
Alkout AM, Weir DM, Blackwell CC. Increased inflammatory responses of persons of blood group O to Helicobacter pylori. J INFECT DIS. 2000 Apr 1;181(4):1364–1369.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 American Journal of Psychiatric Rehabilitation
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License permitting all use, distribution, and reproduction in any medium, provided the work is properly cited.
This work is licensed under a 
