Study of Psychological Dysfunction and Cognitive impairment in Alcohol Dependence Patients
DOI:
https://doi.org/10.69980/ajpr.v28i5.900Keywords:
Psychological dysfunction, Cognitive impairment and Alcohol dependenceAbstract
Alcoholism has a higher prevalence of comorbid psychiatric disorders than the general population. Heavy drinking has been shown to affect the neuropsychological performance (e.g., memory functions) of young people and may impair the growth and integrity of certain brain structures. Depression is also a common comorbid condition in recently detoxified alcoholics and may relate to both the physiological effects of alcohol withdrawal and psychological factors such as remorse over one's actions. An objective of the study will be to assess psychological dysfunction and cognitive impairment in alcohol-dependence patients and to compare them with healthy controls. Methodology- a Cross-sectional, non-interventional, case-control study would be applied for the present study. A total of 40 participants consisting of 20 Alcohol dependent patients and 20 Healthy controls will be randomly selected for the study. Data will be collected from the Drug De-addiction center in Delhi. Alcohol screening tools Michigan Alcohol Screening test (MAST) will be applied for alcohol dependence, Brief symptoms inventory to assess psychological dysfunction, Montreal cognitive assessment (MOCA) will assess for cognitive impairment. Depending on the nature of data appropriate statistical analysis would be carried out for the same.
References
1. Abrams, K., Kushner, M., Medina, K. L., and Voight, A. (2001). The pharmacologic and expectancy effects of alcohol on social anxiety in individuals with social phobia. Drug Alcohol Depend. 64, 219–231. doi:10.1016/S0376-8716(01)00125-9
2. Boschloo, L., Vogelzangs, N., Smit, J. H., Van der Brink, W., Veltman, D. J., Beekman, A. T., et al. (2011).
3. Comorbidity and risk indicators for alcohol use disorders among persons with anxiety and/or depressive disorders: findings from the Netherlands Study of Depression and Anxiety (NESDA). J. Affect. Disord. 131, 233–242. doi: 10.1016/j.jad.2010.12.014
4. Fink, D. S., Gallaway, M. S., Tamburrino, M. B., Liberzon, I., Chan, P., Cohen, G. H., et al. (2016). Onset of alcohol use disorders and comorbid psychiatric disorders in a military cohort: are there critical periods for prevention of alcohol use disorders? Prev. Sci. 17, 1–10. doi: 10.1007/s11121-015-0624-1
5. Gautham, M. S., Gururaj, G., Varghese, M., Benegal, V., Rao, G. N., Kokane, A., ... &Shibukumar, T. M. (2020). The National Mental Health Survey of India (2016): Prevalence, socio-demographic correlates and treatment gap of mental morbidity. International Journal of Social Psychiatry, 66(4), 361-372.
6. Pitel, A. L., Beaunieux, H., Witkowski, T., Vabret, F., Guillery‐Girard, B., Quinette, P., & Eustache, F. (2007). Genuine episodic memory deficits and executive dysfunctions in alcoholic subjects early in abstinence. Alcoholism: Clinical and Experimental Research, 31(7), 1169-1178.
7. Pitel, A. L., Rivier, J., Beaunieux, H., Vabret, F., Desgranges, B., & Eustache, F. (2009). Changes in the episodic memory and executive functions of abstinent and relapsed alcoholics over a 6‐month period. Alcoholism: Clinical and Experimental Research, 33(3), 490-498.
8. Woods, A. J., Porges, E. C., Bryant, V. E., Seider, T., Gongvatana, A., Kahler, C. W., & Cohen, R. A. (2016). Current heavy alcohol consumption is associated with greater cognitive impairment in older adults. Alcoholism: clinical and experimental research, 40(11), 2435-2444.
9. Zahr NM, Pfefferbaum A. Alcohol’s effects on the brain: neuroimaging results in humans and animal models. Alcohol Res. 2022;42(1):1–18.
10. Sullivan EV, Harris RA. Impact of alcohol on neurocognitive function. HandbClin Neurol. 2022; 185:165–78.
11. MacDonald C, Brophy K, Coroiu A, Braehler E, Körner A. The Brief Symptom Inventory-9 (BSI-9): development and validation in a German general population sample. BMC Psychol. 2024;12(1):413.
12. Zahr NM, Pfefferbaum A. Alcohol’s effects on the brain: neuroimaging results in humans and animal models. Alcohol Res. 2024;44(1):01–15.
13. Koob GF, Schulkin J. Addiction and stress: an allostatic view. Neuropsychopharmacology. 2024;49(2):311–325.
14. Suchy-Dicey AM, Vo TT, Oziel K, Buchwald D, Rhoads K, French BF. Psychometric reliability and validity of the Montreal Cognitive Assessment (MoCA). Assessment. 2025;32(4):608–621.
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