“Formulation And Evaluation Of Nutrasudil Insitu Gel”
DOI:
https://doi.org/10.69980/ajpr.v28i2.938Keywords:
ophthalmic solutions, viscosity enhancers, Cold method, Gelling timeAbstract
In present study, ophthalmic eye drops solution are available in the Indian market with strength of 0.02 w/v. As of now, the Indian market does not have any formulations of In- situ gel. Netarsudil ophthalmic solutions have an extensive drug loss during the time of administration due to that drug may not reach at the site of action. As a result, this medication was created as In-situ gel to improve patient compliance and increase the bioavailability of Netarsudil. In-situ gel was prepared by adopting Cold method, which is relatively easy and using pH triggered system. Preliminary studies were taken by using different excipients gelling agent and viscosity enhancers. Sodium alginate, Carbopol 940 and HPMC E4M, HPMC K4M, HPMC E50LV used as gelling agent and viscosity enhancers respectively. By this check best polymer for the optimization study. Three dependent responses, R1 (Gelling time), R2 (Viscosity), and R3 (% CDR), were explored in order to optimise the formulation using the two parameters F1 (Quantity of HPMC E50LV- viscosity enhancers) and F2 (Carbopol 940- gelling agent). Formulations with HPMC E50LV at 1.5mg and Carbopol 940 at 0.3mg (D2) were shown to have comparably better.
References
1. Mandal S, Thimmisetty M. K., Prabhushankar G. L., Geetha M.S..: Formulation and evaluation of an in-situ gel-forming ophthalmic formulation of moxifloxacin hydrochloride. Int Pharma Investing 2012: Vol 2(2),78-82.
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769798/
3. https://www.mayoclinic.org/diseases-conditions/glaucoma/symptoms-causes/syc-20372839
4. https://www.sciencedirect.com/science/article/abs/pii
5. Anatomyof aneye/ www.researchgate.com/publication
6. Tripathi KD .Essentials of medica lpharmacology .JP Medical
7. Ltd;2013 Sep30.
8. Mohanty D, Bakshi V, Simharaju N, Haque MA, Sahoo CK. A review on in situ gel: a novel drug delivery system. Int. J. Pharm. Sci. Rev. Res. 2018;50(1):175-81.
9. Chand P, Gnanarajan G, Kothiyal P. In situ gel: A Review. Indian Journal of Pharmaceutical and Biological Research. 2016 Apr 1;4(2):11.
10. Patil PR, Shaikh SS, Shivsharan KJ, Shahi SR. In situ gel: a novel drug delivery system. Indo Am J Pharm Res. 2014;4(11):5406-14.
11. Majeed A, Khan NA. Ocular in situ gel: An overview. Journal of Drug Delivery and Therapeutics. 2019 Jan 15;9(1):337-47.
12. Moin K. Modasiya, Bhupendra G. Prajapati Vishnu M. Patel, Jayvadan K. Patel; Sodium Alginate Based in Situ Gelling System of Famotidine: Preparation and In-Vivo Characterizations; e-Journal of Science & Technology, (1), 5, Jan 2010
13. Gupta H, Jain S, Mathur R, Mishra P, Mishra AK, Velpandian T.Sustained ocular drug delivery from a temperature and pH triggered novel insitugel system Drug delivery.2007 Jan 1;14(8):507-15.
14. https://go.drugbank.com/salts/DBSALT002599
15. Kolling WM. Handbook of pharmaceutical excipients. American Journal of Pharmaceutical Education. 2004;68(1-5):BF1.
16. Kala S, Gurudiwan P, Juyal D. Formulation and evaluation of besifloxacin loaded in situ gel for ophthalmic delivery. Pharmaceutical and Biosciences Journal.2018Apr22:36-40.
17. Ammar HO, Salama HA, Ghorab M, Mahmoud AA. Development of dorzolamide hydrochloride in situ gel nanoemulsion for ocular delivery. Drug development and industrial pharmacy. 2010 Nov 1;36(11):1330-9.
18. Aldawsari MF, Moglad EH, Alotaibi HF, Alkahtani HM, Khafagy ES. Ophthalmic bimatoprost-loaded niosomal in situ gel: preparation, optimization, and in vivo pharmacodynamics study. Polymers. 2023 Nov 6;15(21):4336.
19. Khattab A, Marzok S, Ibrahim M. Development of optimized mucoadhesive thermosensitive pluronic based in situ gel for controlled delivery of Latanoprost: Antiglaucoma efficacy and stability approaches. Journal of Drug Delivery Science and Technology. 2019 Oct 1;53:101134.
20. Makwana SB, Patel VA, Parmar SJ. Development and characterization of in-situ gel for ophthalmic formulation containing ciprofloxacin hydrochloride. Results in pharma sciences. 2016 Jan 1;6:1-6.
21. Vyas U, Gehalot N, Jain V, Mahajan SC. Formulation and Evaluation of Norfloxacin Ocular In-situGel.JournalofDrugDelivery and Therapeutics.2022Oct15;12(5-S):123- 6.
22. Huong,“Ophthalmic composition”-JP5885349B2.”2016.
23. Russel,“Insitu solidifying solutions and methods of making and using there of by”- US10729807B2.” 2020.
24. Chandrashekhar,“Method of making an insitu sustained biodegradable drug delivery implant by filling an artificial tissue cavity” - US11045433B2.” 2021.
25. Dongling,“Insitu gellingdrug deliverysystem”- US9566336B2.”2017.
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