Effect of Yoga on Cardiac Autonomic Function Tests in Obese and Non-Obese Patients with Myocardial Infarction: A Comparative and Interventional Study

Authors

  • Laxmi Yadav PhD Scholar, Department of Physiology, Malwanchal University, Indore, Madhya Pradesh, India
  • Dr. Manila Jain Professor and Head, Department of Physiology, Malwanchal University, Indore, Madhya Pradesh, India
  • Dr. Kamini Savita Senior Resident, Department of Biochemistry, S.N. Medical College, Agra, Uttar Pradesh, India
  • Naman Yadav Research Scholar (Statistics), Amity University, Uttar Pradesh, India

DOI:

https://doi.org/10.69980/ajpr.v29i1.960

Keywords:

Yoga, Heart rate variability, Cardiac autonomic function, Obesity, Myocardial infarction, Lipid profile

Abstract

Background: Obesity and myocardial infarction (MI) both weaken the nervous control of the heart. Low heart rate variability (HRV) after MI is linked with higher mortality. This study compared HRV and lipid profile in obese and non-obese MI patients, and tested the effect of 12 weeks of yoga in obese MI patients.
Methods: This hospital-based study at Index Medical College, Malwanchal University, Indore included 100 obese MI patients (BMI ≥ 25 kg/m²), 100 non-obese MI patients (BMI 18.5–22.9 kg/m²) and 100 healthy controls, aged 35–65 years. Fifty obese MI patients did supervised yoga for 12 weeks along with standard care. HRV (SDNN, RMSSD, LF/HF ratio), lipid profile, HbA1c, Troponin T, CK-MB and QTc were measured. Welch's t-test and the paired t-test were used.
Results: Obese MI patients had lower SDNN (69.9 ± 6.1 vs 83.6 ± 17.9 ms) and RMSSD (17.5 ± 4.9 vs 51.0 ± 11.1 ms) than non-obese MI patients (p < 0.001). They also had higher LDL, total cholesterol, triglycerides, CK-MB and QTc, and lower HDL (all p < 0.001). After yoga, LDL fell by 8.7%, total cholesterol by 22.6% and triglycerides by 30.5%, and HDL rose by 19.5% (all p < 0.001). HRV and BMI did not change significantly.
Conclusion: Obese MI patients have poorer HRV and a worse lipid profile than non-obese MI patients. Twelve weeks of yoga improved the lipid profile but not HRV. Yoga is a useful add-on to standard care after MI.

 

 

References

1.World Health Organization. Cardiovascular diseases (CVDs). Fact sheet. Geneva: WHO; 2025.

2.Prabhakaran D, Jeemon P, Roy A. Cardiovascular diseases in India: current epidemiology and future directions. Circulation. 2016;133(16):1605-20.

3.Misra A, Chowbey P, Makkar BM, Vikram NK, Wasir JS, Chadha D, et al. Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. J Assoc Physicians India. 2009;57:163-70.

4.Karason K, Mølgaard H, Wikstrand J, Sjöström L. Heart rate variability in obesity and the effect of weight loss. Am J Cardiol. 1999;83(8):1242-7.

5.Lambert EA, Esler MD, Schlaich MP, Dawood T, Burman J, Lambert GW. Obesity-associated organ damage and sympathetic nervous activity: a target for treatment? Hypertension. 2019;73(6):1150-9.

6.Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation. 1996;93(5):1043-65.

7.Kleiger RE, Miller JP, Bigger JT Jr, Moss AJ. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol. 1987;59(4):256-62.

8.La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A, Schwartz PJ. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI Investigators. Lancet. 1998;351(9101):478-84.

9.Tyagi A, Cohen M. Yoga and heart rate variability: a comprehensive review of the literature. Int J Yoga. 2016;9(2):97-113.

10.Posadzki P, Kuzdzal A, Lee MS, Ernst E. Yoga for heart rate variability: a systematic review and meta-analysis of randomized clinical trials. Appl Psychophysiol Biofeedback. 2015;40(3):239-49.

11.Christa E, Srivastava P, Chandran DS, Jaryal AK, Yadav RK, Roy A, et al. Effect of yoga-based cardiac rehabilitation on heart rate variability: randomized controlled trial in patients post-MI. Int J Yoga Therap. 2019;29(1):43-50.

12.Prabhakaran D, Chandrasekaran AM, Singh K, Mohan B, Chattopadhyay K, Chadha DS, et al. Yoga-based cardiac rehabilitation after acute myocardial infarction: a randomized trial. J Am Coll Cardiol. 2020;75(13):1551-61.

13.Manchanda SC, Narang R, Reddy KS, Sachdeva U, Prabhakaran D, Dharmanand S, et al. Retardation of coronary atherosclerosis with yoga lifestyle intervention. J Assoc Physicians India. 2000;48(7):687-94.

14.Cramer H, Lauche R, Haller H, Steckhan N, Michalsen A, Dobos G. Effects of yoga on cardiovascular disease risk factors: a systematic review and meta-analysis. Int J Cardiol. 2014;173(2):170-83.

15.Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol. 2018;72(18):2231-64.

16.Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-502.

17.Bazett HC. An analysis of the time-relations of electrocardiograms. Heart. 1920;7:353-70.

18.Billman GE. The LF/HF ratio does not accurately measure cardiac sympatho-vagal balance. Front Physiol. 2013;4:26.

Downloads

Published

2026-01-29